In-clinic and Mobile IV services available for the Phoenix Metro Area!
In-clinic and Mobile IV services available for the Phoenix Metro Area!
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Signal Transduct Target Ther
. 2024 Jan 12;9:17. doi: 10.1038/s41392-023-01704-0
Stem cell-based therapy, as a modality of regenerative medicine, has generated tremendous attention, as it offers new options for patients suffering from previously incurable diseases. Subsequently, thousands of related clinical trials have been registered, covering a wide spectrum of medical problems, such as musculoskeletal and neurological disorders, immune diseases, hematological dysfunctions, and degenerative conditions.
Exosomes are vesicles secreted from mesenchymal stem cells. These vesicles are secreted by almost all cell types to aid in a vast array of cellular functions, including intercellular communication, cell differentiation and proliferation, angiogenesis, stress response, and immune signaling. This ability to contribute to several distinct processes is due to the complexity of exosomes, as they carry a multitude of signaling moieties, including proteins, lipids, cell surface receptors, enzymes, cytokines, transcription factors, and nucleic acids. The favorable biological properties of exosomes including biocompatibility, stability, low toxicity, and proficient exchange of molecular cargos make exosomes prime candidates for tissue engineering and regenerative medicine.
(Cells. 2021 Aug 1;10(8):1959. doi: 10.3390/cells10081959. )
Exosomes are able to pass the blood brain barrier. This allows for exosome signals to initiate healthy communication of brain cells which may optimize brain health and slow neurodegenerative conditions.
Exosomes may help regulate pain of both inflammatory and neuropathic origins while being potentially immunoprotective and anti-inflammatory.
Stem cell-derived exosomes inherit similar therapeutic effects from their parental cell of origin, e.g., tissue regeneration, anti-inflammation and immunomodulation.
We source exosomes from FDA approved laboratories and cGMP labs. The exosomes go through donor testing and are minimally manipulated after umbilical cord extraction then cryo-freezed for preservation. This therapy is only utilized for research and clinical studies.
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